Agent Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

CAS Number

24589-78-4

Formula

C6-H12-F3-N-O-Si

Major Category

Metals

Synonyms

MSTFA; N-Methyl-N-trimethylsilyltrifluoroacetamide; Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-; [ChemIDplus] UN1993

Category

Metalloid Compounds (Silicon)

Description

Colorless liquid; [Sigma-Aldrich MSDS]

Sources/Uses

"Derivatization, especially silylation, is commonly used to identify and quantify both known and unknown compounds using GC-MS. It is not limited to small molecules. Even peptides can be silylated, especially when the introduction of deuterium is desired. N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a very versatile reagent because it can be used to derivatize many of the functional groups commonly found in organic compounds. It operates by attachment of a nonpolar trimethylsilyl (TMS) group." [Sigma-Aldrich]

Comments

Causes decreased immune response in intraperitoneal lethal-dose studies of mice (LDLo = 1,000 mg/kg); [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See "N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide." See "N-Methyl-bis(trifluoroacetamide)."

Exposure Assessment
Explanatory Notes

Vapor pressure = 8.8 mm Hg at 27 deg C; [Sigma-Aldrich MSDS] The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s."

Links to Other NLM Databases
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