Agent Name

Chloroacetone

CAS Number

78-95-5

Formula

C3-H5-Cl-O

Major Category

Other Classes

Synonyms

1-Chloro-2-ketopropane; 1-Chloro-2-oxopropane; 1-Chloro-2-propanone; 1-Chloroacetone; 2-Propanone, 1-chloro-; 3-Chloro-2-propanone; Acetone, chloro-; Acetonyl chloride; Chloracetone [French]; Chloro-2-propanone; Chloroacetone; Chloromethyl methyl ketone; Chloropropanone; Monochloracetone; Monochloroacetone; Monochloropropanone; [ChemIDplus] UN1695

Category

Halogenated Ketones

Description

Colorless to amber liquid with a pungent odor; [ACGIH]

Sources/Uses

Used as a catalyst for polymerization and an intermediate for organic synthesis; Used in 1914 as a war gas; [ACGIH]

Comments

A lacrimator, vesicant, and irritant of the respiratory tract; Causes lacrimation at 5 ppm and with continued exposure irritation of the skin and upper respiratory tract, but not pulmonary edema at low, irritating concentrations; [ACGIH] Causes lachrymation and severe irritation to the respiratory tract; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Ceiling (ACGIH)

1 ppm

Vapor Pressure

12 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

0.39 ppm

Lethal Concentration

LC50 (rat) = 262 ppm/1H

Explanatory Notes

Odor threshold from CHEMINFO; Boiling point = 248 degrees F (120 degrees C); Flash point = 82 degrees F; [CAMEO]

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: