Agent Name

Isobutyronitrile

CAS Number

78-82-0

Formula

C4-H7-N

Major Category

Nitrogen Compounds

Synonyms

1-Cyano-1-methylethane; 2-Cyanopropane; 2-Methylpropane nitrile; 2-ethylpropanenitrile; 2-Methylpropionitrile; Dimethylacetonitrile; Isobutyronitrile; Isopropyl cyanide; Isopropyl nitrile; Isopropylkyanid [Czech]; Isopropylnitrile; Propanenitrile, 2-methyl-; Propanoic acid, 2-methyl-, nitrile; alpha-Methylpropanenitrile; [ChemIDplus] UN2284

Category

Nitriles

Description

Colorless liquid with an almond-like odor; Note: Forms cyanide in the body; [NIOSH]

Sources/Uses

Used in the synthesis of insecticides and gasoline additives; used as a catalyst in the production of polyethylene; [HSDB]

Comments

Isobutyronitrile is hazardous by the oral, skin, or inhalation routes; it causes liver injury in animal feeding studies. Animals inhaling 5500 ppm for one hour have convulsions and die. [HSDB]

Exposure Assessment
Vapor Pressure

32.7 mm Hg

Lethal Concentration

LCLo (rat) = 1,000 ppm/4h

Explanatory Notes

NIOSH REL = 8 ppm; Flash point = 8 deg C;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Chemical Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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