Agent Name

Tetrakis (hydroxymethyl) phosphonium chloride

CAS Number

124-64-1

Formula

C4-H12-O4-P.Cl

Major Category

Other Classes

Synonyms

Phosphonium, tetrakis(hydroxymethyl)-, chloride; Pyroset TKC; Retardol C; THPC; Tetrahydroxymethylphosphonium chloride; Tetrakis(hydroxymethyl)phosphochloride; Tetrakis(hydroxymethyl)phosphonium chloride; Tetrakis-(hydroxymethyl)fosfoniumchlorid [Czech]; Tetramethylolphosphonium chloride; [ChemIDplus]

Category

Phosphorus Compounds

Description

Crystalline solid; [ACGIH] Available commercially as an 80% aqueous solution; [MSDSonline]

Sources/Uses

Used to make crease-resistant and flame-retardant finishes for textiles, e.g., children's sleepwear; [ACGIH] Used as a disinfectant--effective against escherichia coli and staphylococcus aureus, and foot-and-mouth disease virus of cattle; [HSDB]

Comments

Degrades rapidly in the environment in the presence of moisture and sunlight; Tetrakis (hydroxymethyl) phosphonium sulfate (THPS) was a sensitizer in 14 of 20 guinea pigs; Tetrakis (hydroxymethyl) phosphonium chloride (THPC) was also designated a dermal sensitizer; THPS did not inhibit acetylcholinesterase in vitro; Rats and mice given repeated high oral doses have liver damage; 14-day gavage studies at 150 mg/kg body weight caused hind limb paralysis in rats; [ACGIH] Toxic if swallowed; May cause skin irritation and sensitization; May cause respiratory sensitization; [Sigma-Aldrich MSDS] See "Tetrakis (hydroxymethyl) phosphonium sulfate."

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

2 mg/m3

Vapor Pressure

1.13E-7 mm Hg

Explanatory Notes

VP = 1 mm Hg @ 77 deg F; [CAMEO]

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

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Health Studies

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Toxicity Information

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Chemical Information

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