Agent Name

1-Bromopropane

CAS Number

106-94-5

Formula

C3-H7-Br

Major Category

Solvents

Synonyms

Propane, 1-bromo-; Propyl bromide; n-Propyl bromide; [ChemIDplus] n-Propylbromide; Propylbromide;1-BP; [ACGIH] UN2344

Category

Brominated Solvents

Description

Colorless liquid; [ACGIH]

Sources/Uses

Used as a solvent substitute "to clean metals and electronics, in adhesive and coating applications, and in aerosol propellant applications." Has also been used to replace perchloroethylene in dry cleaning; [ACGIH]

Comments

If left on clothes, may cause reddening of skin; [CHRIS] A case of peripheral neuropathy was reported in a 19 year old male after 2 months of occupational exposure to a degreasing solvent containing 95.5% 1-BP. Reproductive toxicity and hepatotoxicity are observed in animals repeatedly exposed to levels above 250 ppm and 200 ppm, respectively. LOAEL was 1.28 ppm for loss of vibratory sensation in toes and reduced RBC count in 60 factory workers exposed to 1-BP. TLV Basis: CNS impairment; peripheral neuropathy; hematologic effects, reproductive, and developmental toxicity; [ACGIH] 1-BP causes neurotoxicity and reproductive toxicity in animal studies. A study of 27 workers producing 1-BP in a Chinese factory found evidence of toxicity to the CNS and peripheral nerves. [PMID 15345346] Six cases of neurotoxicity (possible central distal axonopathy) were reported among foam cushion gluers. [PMID 17453879] A cross-sectional study of 60 female and 26 male workers in three 1-BP factories in China found neurotoxicity in females exposed to >1.28 ppm. [PMID 20657306] Potential adverse effects include CNS depression and anesthesia; [HSDB] See "Carcinogenicity of some industrial chemicals," Volume 115. [IARC, News Release, 23 February 2016] See "2-Bromopropane."

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

0.1 ppm

Vapor Pressure

146 mm Hg

Lethal Concentration

LC50 (rat) =253,000 mg/m3/30 min

Reference Link

Neurologic Illness Associated with Occupational Exposure to the Solvent 1-Bromopropane --- New Jersey and Pennsylvania, 2007--2008

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: