Agent Name

1-Chloro-2-propanol

CAS Number

127-00-4

Formula

C3-H7-Cl-O

Major Category

Other Classes

Synonyms

1-Chloro-2-hydroxypropane; 1-Chloro-2-propanol; 1-Chloroisopropyl alcohol; Chloroisopropyl alcohol; Propene chlorohydrin; sec-Propylene chlorohydrin; [ChemIDplus] UN2611

Category

Halogenated Alcohols

Description

Colorless liquid with a faintly ethereal odor; [ACGIH]

Sources/Uses

Used as a chemical intermediate; A residue in foods that have been fumigated or cold steriized with propylene oxide; [ACGIH]

Comments

Causes damage to the liver and other organs in animal feeding studies; Critical Effects: reproductive; genotoxic; [ACGIH] No adverse effects on fertility in a chronic feeding study of rats; Increased testis weights and sperm abnormalities--possible evidence of slight reproductive toxicity; [NTP] General anesthetic effect in lethal dose feeding studies of guinea pigs; [RTECS] An irritant of the skin, eyes, and respiratory tract; [CAMEO] See "2-Chloro-1-propanol."

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

1 ppm

Vapor Pressure

4.9 mm Hg

Lethal Concentration

LC50 (rat) = 1000 ppm/4H

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

ACGIH Carcinogen

Not Classifiable

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent: