Agent Name

Malononitrile

CAS Number

109-77-3

Formula

C3-H2-N2

Major Category

Nitrogen Compounds

Synonyms

Cyanoacetonitrile; Dicyanomethane; Dwumetylosulfotlenku [Polish]; Malonic acid dinitrile; Malonic dinitrile; Malonodinitrile; Methane, dicyano-; Methylene cyanide; Methylenecyanide; Methylenedinitrile; Nitril kyseliny malonove [Czech]; Nitrile kyseliny malonove [Czech]; Propanedinitrile; Propanedinitrite; [ChemIDplus] UN2647

Category

Nitriles

Description

White powder or colorless crystals; Note: Melts above 90 degrees F. Forms cyanide in the body; [NIOSH]

Sources/Uses

Used in organic synthesis of thiamine, an anti-cancer drug, acrylic fibers, and dyes; used as a leaching agent for gold; [HSDB]

Comments

The toxicity of this compound is due to liver metabolism and the release of cyanide. Animals show liver injury after subcutaneous doses. [HSDB] A severe irritant of the skin and eyes; Violent polymerization may occur if heated above 266 deg F or contacts strong bases at lower temperatures; [CAMEO]

Exposure Assessment
Vapor Pressure

0.2 mm Hg

Lethal Concentration

LC50 (rat) = 200-300 mg/m3/2H

Explanatory Notes

NIOSH REL = 3 ppm; Flash point = 266 deg F;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Chemical Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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