Agent Name

Benzotrichloride

Alternative Name

Benzyl trichloride

CAS Number

98-07-7

Formula

C7-H5-Cl3

Major Category

Solvents

Synonyms

1-(Trichloromethyl)benzene; Benzene, (trichloromethyl)-; Benzenyl trichloride; Benzoic trichloride; Benzotrichloride; Benzotricloruro [Spanish]; Benzyl trichloride; Benzylidyne chloride; Chlorure de benzenyle [French]; Chlorure de benzylidyne [French]; Phenyl chloroform; Phenylchloroform; Phenyltrichloromethane; Toluene trichloride; Toluene, alpha,alpha,alpha,-trichloro-; Trichloormethylbenzeen [Dutch]; Trichlormethylbenzol [German]; Trichloromethylbenzene; Trichlorophenylmethane; Triclorometilbenzene [Italian]; Triclorotoluene [Italian]; UN2226; [ChemIDplus]

Category

Chlorinated Aromatics

Description

Clear to yellow liquid with a penetrating odor; [ACGIH]

Sources/Uses

Used as a chemical intermediate; [ACGIH]

Comments

Exposure of mice and rats to 12.5 ppm for 2 hours causes CNS excitation, eye and respiratory tract irritation, and slowed respiration. "Critical Effects" are irritation; cancer. [ACGIH] Reacts with water to form hydrochloric acid; A skin and eye irritant; In inhalation studies, 5/6 rats die after exposure of 125 ppm for 4 hours; [CHEMINFO] Burns skin, corrosive to eyes, and risk of lung edema after inhalation; [ICSC] In high-dose feeding studies of animals, mild histological changes in the liver occur. [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Yes

Ceiling (ACGIH)

0.1 ppm

Vapor Pressure

0.2 mm Hg

Lethal Concentration

LC50 (rat) = 19 ppm/2H

Half Life

Elimination 1/2 time of 22 hours for blood and 14 hours for tissue; [ACGIH]

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.