Agent Name

Phenyl isothiocyanate

CAS Number

103-72-0

Formula

C7-H5-N-S

Major Category

Nitrogen Compounds

Synonyms

Benzene, isothiocyanato-; Benzene-1-isothiocyanate; Fenylisothiokyanat [Czech]; Isothiocyanatobenzene; Isothiocyanic acid phenyl ester; PITC; Phenylisothiocyanate; Phenyl mustard oil; Phenyl thioisocyanate; Phenylsenfoel [German]; Thiocarbanil; Benzene, isothiocyanato-; Isothiocyanic acid, phenyl ester; [ChemIDplus] UN2927

Category

Isothiocyanates

Description

Liquid; [Merck Index] Colorless liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Used to derive primary and secondary amines, in sequencing of peptides by Edman degradation, and in amino acid analysis by HPLC; [Merck Index]

Comments

Dermal studies of guinea pigs demonstrate severe irritation, good absorption, and sensitization; Effects on thyroid function (decreased serum T4 levels) observed in 4-week oral study of rats; [ToxPlanet: EPA - PPRTV] Causes burns and lachrymation; May cause skin and respiratory sensitization; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; Targets the kidney and bladder; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

1.5 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic liquid, corrosive, organic, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: