Agent Name

Phenylhydrazine hydrochloride

CAS Number

59-88-1

Formula

C6-H8-N2.Cl-H

Major Category

Nitrogen Compounds

Synonyms

Hydrazine, phenyl-, hydrochloride; Phenylhydrazin hydrochlorid [German]; Phenylhydrazine monohydrochloride; Phenylhydrazine-HCl; Phenylhydrazinium chloride; Hydrazine, phenyl-, monohydrochloride; [ChemIDplus] UN2572

Category

Hydrazines

Description

White to tan solid with a mild aromatic odor; [CAMEO] White powder; [Alfa Aesar MSDS]

Sources/Uses

Used to make dyes, antipyrine, and nitron (explosives stabilizer); as a reagent for sugars, aldehydes, and ketones; and as a therapeutic hemolytic; [Merck Index]

Comments

Causes cyanosis, corrosion, and weight loss in dermal lethal-dose studies of rabbits; Causes methemoglobinemia, respiratory stimulation, and normocytic anemia in intraperitoneal lethal-dose studies of rats; [RTECS] Overexposure may cause skin sensitization, hemolytic anemia, dyspnea, cyanosis, jaundice, kidney injury, vascular thrombosis, and occupational cancer; [Merck Index] An irritant and chronic poison; Ingestion may cause jaundice, anorexia, nausea, vascular thrombosis, anemia, and liver injury; [CHRIS] A skin and strong eye irritant; May cause skin sensitization; Toxic by ingestion, inhalation, and skin absorption; Risk of irreversible adverse health effects; Suspected to cause genetic defects and cancer; [Alfa Aesar MSDS] See "Phenylhydrazine."

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylhydrazine."

Adverse Effects
Skin Sensitizer

Yes

Anemia

Anemia, Hemolytic

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: