Agent Name

Phenylmethylsulfonyl fluoride

Alternative Name

PMSF

CAS Number

329-98-6

Formula

C7-H7-F-O2-S

Major Category

Other Uses

Synonyms

Benzenemethanesulfonyl fluoride; Benzylsulfonyl fluoride; Benzylsulphonyl fluoride; PMSF; Phenylmethanesulfonyl fluoride; alpha-Toluenesulfonyl fluoride; alpha-Toluenesulphonyl fluoride; [ChemIDplus] UN2928

Category

Biochemical Research

Description

Colorless solid; [Merck Index] White crystals; [Sigma-Aldrich MSDS]

Sources/Uses

A serine and cysteine protease inhibitor; Used as a protease inhibitor in research and to prevent proteolytic degradation in protein purification; [Merck Index]

Comments

Causes convulsions and multiple enzyme effects in acute intraperitoneal studies of mice; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Targets the nerves, heart, blood, and eyes; [Sigma-Aldrich MSDS] See "Methanesulfonyl fluoride."

Exposure Assessment
BEI

Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)

TLV (ACGIH)

2.5 mg/m3, as F

PEL (OSHA)

2.5 mg/m3, as F

MAK

1 mg/m3, inhalable fraction, as F

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.