Agent Name | Phenylmethylsulfonyl fluoride |
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Alternative Name | PMSF |
CAS Number | 329-98-6 |
Formula | C7-H7-F-O2-S |
Major Category | Other Uses |
Synonyms | Benzenemethanesulfonyl fluoride; Benzylsulfonyl fluoride; Benzylsulphonyl fluoride; PMSF; Phenylmethanesulfonyl fluoride; alpha-Toluenesulfonyl fluoride; alpha-Toluenesulphonyl fluoride; [ChemIDplus] UN2928 |
Category | Biochemical Research |
Description | Colorless solid; [Merck Index] White crystals; [Sigma-Aldrich MSDS] |
Sources/Uses | A serine and cysteine protease inhibitor; Used as a protease inhibitor in research and to prevent proteolytic degradation in protein purification; [Merck Index] |
Comments | Causes convulsions and multiple enzyme effects in acute intraperitoneal studies of mice; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; Targets the nerves, heart, blood, and eyes; [Sigma-Aldrich MSDS] See "Methanesulfonyl fluoride." |
Exposure Assessment | |
BEI | Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.) |
TLV (ACGIH) | 2.5 mg/m3, as F |
PEL (OSHA) | 2.5 mg/m3, as F |
MAK | 1 mg/m3, inhalable fraction, as F |
Explanatory Notes | The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s." |
Adverse Effects | |
Toxic Pneumonitis | Yes |
Dermatotoxin | Skin Burns |
Links to Other NLM Databases | |
Toxicity Information | |
Chemical Information | |
Related Information in HazMap | |
Other Information | No other related information on this agent was found. |