Agent Name

m-Phenylenediamine

CAS Number

108-45-2

Formula

C6-H8-N2

Major Category

Nitrogen Compounds

Synonyms

1,3-Diaminobenzene; 1,3-Phenylenediamine; 3-Aminoaniline; Benzene, 1,3-diamino-; C.I. Developer 11; CI Developer 11; Developer 11; Developer C; Developer H; Developer M; Direct Brown BR; Direct Brown GG; Metaphenylenediamine; m-Aminoaniline; m-Benzenediamine; m-Diaminobenzene; m-Fenylendiamin [Czech]; m-Phenylenediamine; meta-Aminoaniline; meta-Benzenediamine; meta-Diaminobenzene; UN1673; [ChemIDplus]

Category

Amines, Aromatic

Description

White crystals that change to red on exposure to light and air; [CHEMINFO]

Sources/Uses

Used to make diisocyanates for the production of polyurethane foams and other resins and polymers; Also used as a corrosion inhibitor, curing agent, photographic developer, and intermediate for other chemical products; [CHEMINFO] Used to make dyes, to develop dyes, to dye hair, and to cure epoxy resins; [ACGIH]

Comments

In acute studies at lethal doses (650 mg/kg), animals have tremors, convulsions, cyanosis, and methemoglobinemia. In subchronic studies, rats have increased liver weights. "Critical Effects" are irritation; liver; Confirmed Animal Carcinogen with Unknown Relevance to Humans; [ACGIH] Danger of skin sensitization; [MAK]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.1 mg/m3

Vapor Pressure

0.0018 mm Hg

Explanatory Notes

Melting Point = 145-147 deg F; [CAMEO]

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: