Agent Name

4-Chloro-2-toluidine

Alternative Name

4-Chloro-o-toluidine

CAS Number

95-69-2

Formula

C7-H8-Cl-N

Major Category

Nitrogen Compounds

Synonyms

2-Amino-5-chlorotoluene; 2-Methyl-4-chloroaniline; 3-Chloro-6-aminotoluene; 4-Chloro-2-methylaniline; 4-Chloro-2-methylbenzeneamine; 4-Chloro-2-toluidine; 4-Chloro-6-methylaniline; 4-Chloro-o-toluidine; 5-Chloro-2-aminotoluene; Amarthol Fast Red TR Base; Asymmetric meta-chloro-ortho-toluidine; Azoene Fast Red TR Base; Azoic Diazo Component 11, base; Benzenamine, 4-chloro-2-methyl-; Brentamine Fast Red TR Base; Daito Red Base TR; Deval Red K; Deval Red TR; Diazo Fast Red TRA; Fast Red 5CT Base; Fast Red Base TR; Fast Red TR; Fast Red TR Base; Fast Red TR11; Fast Red TRO Base; Kako Red TR Base; Kambamine Red TR; Mitsui Red TR Base; Red Base Ciba IX; Red Base IRGA IX; Red Base NTR; Red TR Base; Sanyo Fast Red TR Base; Tulabase Fast Red TR; o-Toluidine, 4-chloro-; p-Chloro-o-toluidine; para-Chloro-ortho-toluidine; [ChemIDplus]

Category

Amines, Aromatic

Description

Grayish-white crystalline solid; [IARC]

Sources/Uses

Used in the past to manufacture azo dyes and chlordimeform; [IARC]

Comments

4-Chloro-2-toluidine is known to cause methemoglobinemia in humans. Two of three cohort studies showed high relative risks for workers exposed to this chemical in dye and chlordimeform production. [IARC] Induces genetic damage in germ cells of humans or animals (3A); [MAK]

Restricted

No longer in production or use in most countries since the 1980s; [IARC]

Exposure Assessment
Vapor Pressure

0.04 mm Hg

Adverse Effects
Reproductive Toxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.