Agent Name

Dimethyl sulfoxide

CAS Number

67-68-5

Formula

C2-H6-O-S

Major Category

Solvents

Synonyms

DMS-70; DMS-90; DMSO; Deltan; Demasorb; Demavet; Demeso; Demsodrox; Dermasorb; Dimethyl sulfoxide; Dimethyl sulphoxide; Dimethyli sulfoxidum [INN-Latin]; Dimethylsulfoxide; Dimethylsulfoxyde [INN-French]; Dimetil sulfoxido [INN-Spanish]; Dimetilsolfossido [DCIT]; Dimexide; Dipirartril-tropico; Dolicur; Doligur; Domoso; Domoso (Veterinary); Dromisol; Durasorb; Gamasol 90; HSDB 80; Hyadur; Infiltrina; M 176; Methane, sulfinylbis-; Methyl sulfoxide; Methylsulfinylmethane; Rimso-5; Rimso-50; SQ 9453; Somipront; Sulfinylbis(methane); Syntexan; Topsym; [ChemIDplus]

Category

Other Solvents

Description

Colorless liquid that is odorless or has a slight odor of sulfur, garlic, or oysters; [CHEMINFO]

Sources/Uses

Used as a pharmaceutical, a solvent for polymerization and chemical extractions, a paint remover, a preservative for organ transplantation; Occurs naturally in ground water and in grains, vegetables, and many other foods; [CHEMINFO] Used as a solvent for many organic compounds; Also used in industrial cleaners; [HSDB]

Comments

A skin and eye irritant; May cause CNS depression after inhalation, ingestion, or skin absorption of high doses; Long term use may cause adverse effects to the liver and blood; [ICSC] Rats experienced "no significant effects" after inhalation of 200 mg/m3 (62.8 ppm) for 30 days. After skin absorption, humans may experience garlic odor on the breath, headache, nausea, and dizziness. DMSO enhances the absorption of other drugs. [CHEMINFO] Health effects after inhalation of high concentrations may include headache, dizziness, and sedation. [CAMEO] "Dermal doses as high as 1 g/kg per day have been shown to have no significant adverse clinical effects in well-controlled human studies." [AIHA]

Exposure Assessment
MAK

50 ppm

WEEL

250 ppm

Vapor Pressure

0.61 mm Hg

Lethal Concentration

LC50 (rat) >1600 mg/m3 (aerosol)/4 hr; [CHEMINFO]

Explanatory Notes

MP= 65 degrees F; BP = 372 degrees F;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: