Agent Name

Tetramethyl succinonitrile

CAS Number

3333-52-6

Formula

C8-H12-N2

Major Category

Nitrogen Compounds

Synonyms

2,2,3,3-Tetramethylbutanedinitrile; CP 75475; TMSN; Tetramethylbutanedinitrile; Tetramethylsuccinic acid dinitrile; Tetramethylsuccinodinitrile; Tetramethylsuccinonitrile; Tetramethylsuccinotrile; Tetramethylsukcinonitril [Czech]; [ChemIDplus]

Category

Nitriles

Description

Colorless, odorless solid; Note: Forms cyanide in the body; [NIOSH]

Sources/Uses

TMSN is a decomposition product formed from the heating of a blowing agent, azo-bisisobutyronitrile, during the production of vinyl foam; [ACGIH]

Comments

Convulsions and coma have been reported in workers manufacturing vinyl foam products. The toxicology is similar to that of other aliphatic nitriles. [ACGIH]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm

PEL (OSHA)

0.5 ppm

IDLH (NIOSH)

5 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5hour exposure at this concentration [Hecht and Kimmerle 19561957 as quoted by Reinl 1957]. . . . Human data: None relevant for use in determining the revised IDLH.

Lethal Concentration

LCLo (rat) = 60 ppm/2H

Explanatory Notes

NIOSH REL = 0.5 ppm; See "2018 Notice of Intended Changes." [TLVs and BEIs]

Adverse Effects
Other Poison

Chemical Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: