Agent Name

Coumaphos

CAS Number

56-72-4

Formula

C14-H16-Cl-O5-P-S

Major Category

Pesticides

Synonyms

3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate; 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester; 3-Chloro-4-methylumbelliferone O-ester with O,O-diethyl phosphorothioate; 3-Chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin; 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate; 3-Chloro-7-hydroxy-4-methyl-coumarin O-ester with O,O-diethyl phosphorothioate; Agridip; Asunthol; Asuntol; Azunthol; Baymix; Baymix 50; CO-Ral; Coumafos; Coumafosum [INN-Latin]; Coumaphos; Coumaphos [ISO]; Coumarin, 3-chloro-7-hydroxy-4-methyl-, O-ester with O,O-diethyl phosphorothioate; Cumafos [Dutch]; Cumafos [INN-Spanish]; Cumafosum; Diethyl 3-chloro-4-methylumbelliferyl thionophosphate; Diethyl thiophosphoric acid ester of 3-chloro-4-methyl-7-hydroxycoumarin; Diethyl-O-(3-chloro-4-methyl-7-coumarinyl) phosphorothioate; Diolice; Meldane; Meldone; Muscatox; Negashunt; Negasunt; O,O-Diaethyl-O-(3-chlor-4-methyl-cumarin-7-yl)-monothiophosphat [German]; O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate; O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)phosphorothioate; O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-benzopyran-7-yl)phosphorothioate; O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2h-benzopyran-7-yl); phosphorothioate; O,O-Diethyl O-(3-chloro-4-methyl-7-coumarinyl)phosphorothioate; O,O-Diethyl O-(3-chloro-4-methylcoumarinyl-7) thiophosphate; O,O-Diethyl O-(3-chloro-4-methylumbelliferone) thiophosphate; O,O-Diethyl O-(3-chloro-4-methylumbelliferyl)phosphorothioate; O,O-Diethyl-O-(3-chloor-4-methyl-cumarin-7-yl)monothiofosfaat [Dutch]; O,O-Dietil-O-(3-cloro-4-metil-cumarin-7-il-monotiofosfato); [Italian]; O-(3-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl phosphorothioate; O-(3-Chloro-4-methyl-7-coumarinyl) O,O-diethylphosphorothioate; O-3-Chloro-4-methyl-7-coumarinyl O,O-diethyl phosphorothioate; OMS 485; Phosphorothioic acid, O,O-diethyl ester, O-ester with 3-chloro-7-hydroxy-4-methylcoumarin; Phosphorothioic acid, O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl) O,O-diethyl ester; Resitox; Suntol; Thiophosphate de O,O-diethyle et de O-(3-chloro-4-methyl-7-coumarinyle) [French]; Umbethion; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Brownish crystals with a slight odor of sulfur; [CAMEO]

Sources/Uses

"Used for the control of a wide variety of livestock insects including cattle grubs, lice, scabies, flies, and ticks; the common ectoparasites of sheep, goats, horse, swine, and poultry as well as for screwworms in all these animals." [CAMEO] Used as an insecticide and ascaricide for direct application to cattle, goats, horses, sheep, and swine;

Comments

The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Reference Link

EXTOXNET PIP - COUMAPHOS

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.05 mg/m3, inhalable fraction and vapor

Vapor Pressure

9.7E-8 mm Hg

Lethal Concentration

LC50 (rat) = 303 mg/m3

Half Life

There was no bioaccumulation in rats. 5% of a dermal dose and 70% of an oral dose were eliminated in 7 days. [EXTOXNET]

Adverse Effects
Other Poison

Organophosphate

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: