Agent Name

Dimethyl disulfide

CAS Number




Major Category

Other Classes


2,3-Dithiabutane; Dimethyldisulfide; Disulfide, dimethyl; DMDS; Methyl disulfide; Methyldisulfide; Methyldithiomethane; Paladin; Dimethyl disulphide; [ChemIDplus] MDS; Methyl disulphide; [CHEMINFO] (Methyldithio)methane; Sulfa-Hitech; [CAMEO] Dimethyldisulfid; Disulfuro de dimetilo; Disulfure de dimethyle; [ToxPlanet: ECHA REACH Registrations] UN2381


Sulfur Compounds


Colorless, oily liquid with a garlic-like odor; [CAMEO] Strong, nauseating odor; [CHEMINFO] Clear light yellow liquid with a stench; [Sigma-Aldrich MSDS]


Used as a chemical intermediate: [CAMEO] Released in Kraft pulping to make paper; Also used as a "gas well down hole process aid"; Proposed to replace methyl mercaptan as a jet fuel additive; [NTP] Occupational exposure also occurs at sewage treatment plants. It occurs naturally in many foods. [HSDB] Also used as a sulfiding agent in refineries, a solvent for sulfur, to reduce coke deposits in the petrochemical industry, an artificial flavoring agent, and a corrosion inhibitor; [CHEMINFO] Used to flavor animal feeds; [ToxPlanet: EFSA - FEEDAP] Used as a flavoring agent; [FDA]


A mild skin irritant, dimethyl disulfide is toxic by inhalation, skin absorption, and ingestion. Workers are warned by the nauseating odor, but those exposed to high concentrations may experience fatigue, dyspnea, and upper respiratory tract irritation. At lethal concentrations, animals suffer severe lung injury and paralysis of respiratory muscles. [CHEMINFO] Showed weak to moderate sensitizing potential in local lymph node assay (LLNA) of mice; [ToxPlanet: EPA - TSCATS] An eye, respiratory tract, and mild skin irritant; May cause CNS effects; [ICSC] Safe when used as a flavoring agent in food; [JECFA] A strong eye irritant; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS]

Exposure Assessment
Skin Designation (ACGIH)



0.5 ppm

Vapor Pressure

28.7 mm Hg

Odor Threshold Low

0.00078 ppm

Odor Threshold High

0.0036 ppm

Lethal Concentration

LC50 (rat) = 15.85 mg/m3/2hr

Explanatory Notes

Odor threshold (detection) from CHEMINFO;

Adverse Effects
Toxic Pneumonitis



Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: