Agent Name

Dimethyl disulfide

CAS Number

624-92-0

Formula

C2-H6-S2

Major Category

Other Classes

Synonyms

2,3-Dithiabutane; Dimethyldisulfide; Disulfide, dimethyl; DMDS; Methyl disulfide; Methyldisulfide; Methyldithiomethane; Paladin; Dimethyl disulphide; [ChemIDplus] MDS; Methyl disulphide; [CHEMINFO] (Methyldithio)methane; Sulfa-Hitech; [CAMEO] Dimethyldisulfid; Disulfuro de dimetilo; Disulfure de dimethyle; [ToxPlanet: ECHA REACH Registrations] UN2381

Category

Sulfur Compounds

Description

Colorless, oily liquid with a garlic-like odor; [CAMEO] Strong, nauseating odor; [CHEMINFO] Clear light yellow liquid with a stench; [Sigma-Aldrich MSDS]

Sources/Uses

Used as a chemical intermediate: [CAMEO] Released in Kraft pulping to make paper; Also used as a "gas well down hole process aid"; Proposed to replace methyl mercaptan as a jet fuel additive; [NTP] Occupational exposure also occurs at sewage treatment plants. It occurs naturally in many foods. [HSDB] Also used as a sulfiding agent in refineries, a solvent for sulfur, to reduce coke deposits in the petrochemical industry, an artificial flavoring agent, and a corrosion inhibitor; [CHEMINFO] Used to flavor animal feeds; [ToxPlanet: EFSA - FEEDAP] Used as a flavoring agent; [FDA]

Comments

A mild skin irritant, dimethyl disulfide is toxic by inhalation, skin absorption, and ingestion. Workers are warned by the nauseating odor, but those exposed to high concentrations may experience fatigue, dyspnea, and upper respiratory tract irritation. At lethal concentrations, animals suffer severe lung injury and paralysis of respiratory muscles. [CHEMINFO] Showed weak to moderate sensitizing potential in local lymph node assay (LLNA) of mice; [ToxPlanet: EPA - TSCATS] An eye, respiratory tract, and mild skin irritant; May cause CNS effects; [ICSC] Safe when used as a flavoring agent in food; [JECFA] A strong eye irritant; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm

Vapor Pressure

28.7 mm Hg

Odor Threshold Low

0.00078 ppm

Odor Threshold High

0.0036 ppm

Lethal Concentration

LC50 (rat) = 15.85 mg/m3/2hr

Explanatory Notes

Odor threshold (detection) from CHEMINFO;

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: