Agent Name

Thiamine

Alternative Name

Vitamin B1

CAS Number

59-43-8

Formula

C12-H17-N4-O-S.Cl

Major Category

Biological Agents

Synonyms

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride; Aneurine; Apatate Drape; B-Amin; Beivon; Betabion; Bethiamin; Oryzanin; Oryzanine; Thiacoat; Thiamin; Thiamine monochloride; Thiamine, chloride; Thiaminum [INN-Latin]; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl- chloride; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-chloride; Tiamina [INN-Spanish]; Vitamin B1; Vitaneurin; [ChemIDplus]

Category

Vitamins and Derivatives

Description

Solid with a slight odor; [HSDB] Crystals; [Avocado Research MSDS]

Sources/Uses

An essential vitamin for carbohydrate metabolism and nerve function; Found in whole grains, meats, vegetables, milk, legumes, fruit, rice husks, and yeast; [Merck Index] Used as a nutritional supplement and flavoring agent for foods; [FDA] Used as a medicine, nutrient, in enriched flours, and other foods; [HSDB]

Comments

A water-soluble vitamin used to treat beriberi and Wernicke-Korsakoff syndrome; Anaphylactoid reactions were reported after intravenous injection--rare with new preparations; [Olson, p. 628] Hydrochloride: Safe when used as a flavoring agent in food; [JECFA] Occupational asthma confirmed with broncho-provocation testing in a worker manufacturing cereal; [Malo]

Reference Link

Occupational asthma induced by thiamine in a vitamin supplement for breakfast cereals.

Exposure Assessment
Vapor Pressure

1.8E-10 mm Hg

Adverse Effects
Asthma

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: