Agent Name

12-O-Tetradecanoylphorbol-13-acetate

CAS Number

16561-29-8

Formula

C36-H56-O8

Major Category

Other Uses

Category

Biochemical Research

Description

White solid; [CAMEO] Colorless powder; [Sigma-Aldrich MSDS]

Sources/Uses

Highly effective tumor promoter found in croton oil that stimulates DNA and RNA synthesis; [ChemIDplus] Used in cancer research for studying tumor promotion mechanisms, screening for potential inhibiting agents, and as a positive control for tumor promoting agents; [HSDB]

Comments

Effects numerous cellular functions including inhibition and stimulation growth and function, increased membrane transport of hexose, decreased ovarian and testicular steroidogenesis, interferon-like activity, enhanced capacitation of sperm, and tumor promotion; Embryotoxicity and teratogenicity observed in rodents; [REPROTOX] A skin irritant; A strong purgative by ingestion; [NTP] A skin irritant; Targets the bone marrow, lungs, gastrointestinal tract, blood, and skin; [Sigma-Aldrich MSDS]

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