Agent Name

Terpineol

CAS Number

8000-41-7

Formula

C10-H18-O

Major Category

Biological Agents

Synonyms

Terpineols; [ChemIDplus] Terpineol lilla; [IUCLID] Terpineol, natural; Terpineol mixed isomers; [Sigma-Aldrich MSDS]

Category

Wood Dusts & Extracts

Description

Liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Found as alpha, beta, and gamma isomers; The alpha isomer is obtained from pine needles and used in perfumes, cosmetics, and flavorings; [REPROTOX] Used in the chemical and personal-domestic use industries, as a cleaning/washing agent, disinfectant, food additive, odor agent, and in cosmetics; [IUCLID] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

A moderate skin irritant in rabbits; Not sensitizing in guinea pig maximization test; No evidence of skin sensitization in studies of 25 (12% in petrolatum) and 37 (12.5% in ethanol) volunteers; [IUCLID] Up to ten positive patch test reactions in studies of at least 1,000 patients for fragrance allergies; [ToxPlanet: EC: SCCS] No evidence of skin sensitization in experimental animals; The liver was show to be the target organ of toxicity in 5-week study of rats (fully recovered after 2 weeks); Significantly reduced testis weights and possibly epididymal weights also observed at 750 mg/kg/day; No evidence of reproductive or developmental toxicity; [ToxPlanet: EPA - TSCATS] Included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] An irritant; [Sigma-Aldrich MSDS] See "alpha-Terpineol."

Exposure Assessment
Vapor Pressure

0.03 mm Hg

Lethal Concentration

LC50 (rat) > 4,760 mg/m3/4hr

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: