Agent Name

Simazine

CAS Number

122-34-9

Formula

C7-H12-Cl-N5

Major Category

Pesticides

Synonyms

1-Chloro-3,5-bis(ethylamino)-2,4,6-triazine; 2,4-Bis(aethylamino)-6-chlor-1,3,5-triazin [German]; 2,4-Bis(ethylamino)-6-chloro-s-triazine; 2-Chloro-4,6-bis(ethylamino)-1,3,5-triazine; 2-Chloro-4,6-bis(ethylamino)-s-triazine; 6-Chloro-N,N'-diethyl-1,3,5-triazine-2,4-diamine; 6-Chloro-N2,N4-diethyl-1,3,5-triazine-2,4-diamine; A 2079; AI3-51142; Aktinit S; Amizine; Aquazine; Azotop; Batazina; Batazine FLO; Bitemol; Bitemol S 50; CAT; CAT (herbicide); CDT; CET; Cekusan; Cekusima; Cekuzina-S; G 27692; G-27692; Geigy 27,692; Gesapun; Gesaran; Gesatop; Gesatop 50; H 1803; Herbatoxol S; Herbazin; Herbazin 50; Herbex; Herbex (pesticide); Herboxy; Hungazin DT; Premazine; Primatel S; Primatol S; Princep; Printop; Radocon; Radokor; Simadex; Simanex; Simatsin-neste; Simazin; Simazine; Simazine 80W; Symazine; Tafazine; Tafazine (VAN); Tafazine 50-W; Taphazine; Triazine A 384; W 6658; Yrodazin; Zeapur; [ChemIDplus]

Category

Herbicides, Triazine

Description

Colorless to white crystals; [EXTOXNET]

Sources/Uses

Used as a broadleaf herbicide; [EXTOXNET] Inhibits photosynthesis in weeds after application to soil; Used in crops (apples, oranges, almonds, corn), lawns, and in ponds and aquariums (algicide); [ACGIH]

Comments

"Simazine is slightly to practically nontoxic." Damage to the liver and other organs is observed in high-dose feeding studies of experimental animals. [EXTOXNET] The following herbicides have an oral LD50 of >1 gm/kg and have little or no acute toxicity in humans: Alachlor, Amitrole, Ammonium sulfamate, Atrazine, Dalapon, Dicamba, Glyphosphate, Monuron, Oryzalin, Picloram, Propanil, Simazine, etc. [LaDou, p. 613] For the triazine herbicides, systemic toxicity unlikely unless large amounts are ingested; May cause irritation; [EPA Pesticides, p. 121] Not acutely toxic; TLV Basis: hematologic effects; "In female rats, depression in red blood cell count, hemoglobin and hematocrit and elevations in mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and white blood cell count were seen at both the mid and high doses and the NOEL for these effects was 10 ppm or 0.52 mg/kg/day." Dermatitis has been reported, "but a repeated patch insult test with 50 human subjects showed the 80% wettable powder formulation of simazine was not a primary irritant, defatting agent, or sensitizer." [ACGIH]

Reference Link

EXTOXNET PIP - SIMAZINE

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.5 mg/m3, inhalable particulate matter

Vapor Pressure

2.21E-8 mm Hg

Lethal Concentration

LC50 (rat) = 9800 mg/m3/4H

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: