Agent Name

VM & P Naphtha

CAS Number


Major Category



Ligroin; Painters naphtha; Petroleum ether; Petroleum spirit; Refined solvent naphtha; Varnish Makers' & painters' naphtha; [NIOSH] UN1993


Petroleum, Refined


Clear to yellowish liquid with a pleasant, aromatic odor; There are several different VM & P naphthas based on different petroleum fractions. [ACGIH]


VM & P naphtha has been used as a paint solvent. [ACGIH]


TSCA Definition 2008: A mixture of crude oil distillates with boiling points of 60 deg C to 110 deg C; [ChemIDplus] Petroleum distillates, e.g., VM & P naphtha and kerosene, can cause anesthesia, slowing of reflexes and dermatitis. They may contain n-hexane with the potential to cause peripheral neuropathy. [LaDou, p. 543] Aliphatic and aromatic hydrocarbons cause trivial hepatic injury in animal experiments. [Haddad, 226t] Petroleum ether is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1]

Reference Link

Volatile Substance Abuse

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

Vapor Pressure

40 mm Hg

Lethal Concentration

LC50 (rat) = 3,400 ppm/4h

Explanatory Notes

TLV withdrawn in 2009; See Appendix H: Reciprocal Calculation Method for Certain Refined Hydrocarbon Solvent Vapors; [TLVs and BEIs] Flash point = 20 deg F;

Adverse Effects

CNS Solvent Syndrome


Hepatotoxin, Secondary

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: