Agent Name

Thrombin

CAS Number

9002-04-4

Formula

Unspecified

Major Category

Biological Agents

Synonyms

Thrombin human; Thrombin, topical; Blood-coagulation factor II, activated; Blood-coagulation factor IIa; Bovine thrombin; Evithrom; Factor IIa; Fibrinogenase; Recothrom; Thrombase; Thrombin II; Thrombin JMI; Thrombin, topical (recombinant); Thrombin-C; Thrombinar; Thrombofort; Thrombostat; Tropostasin; [ChemIDplus] Thrombin, from bovine plasma; [Sigma-Aldrich MSDS]

Category

Enzymes

Description

White powder; [Sigma-Aldrich MSDS]

Sources/Uses

Important enzyme in coagulation, produced from prothrombin at the bleeding site; Used as a local hemostatic; [Merck Index] Used in enzyme preparations for binding reconstituted meat; [ExPub: EC: EFSA] "Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions." [Wikipedia]

Comments

A skin and strong eye irritant; May cause skin and respiratory sensitization; Targets the vascular system; [Sigma-Aldrich MSDS] See "ENZYMES."

Adverse Effects
Asthma

Yes

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: