Agent Name


Alternative Name

Tris buffer

CAS Number




Major Category

Other Uses


Tris(hydroxymethyly)amino methane; 2-Amino-2-hydroxymethyl-1,3-propanediol solution; 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-; 2-(Hydroxymethyl)-2-amino-1,3-propanediol; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; 2-Amino-2-methylol-1,3-propanediol; Addex-Tham; Aminotrimethylolmethane; Aminotris(hydroxymethyl)methane; Apiroserum Tham; Methanamine, 1,1,1-tris(hydroxymethyl)-; Methylamine, 1,1,1-tris(hydroxymethyl)-; Pehanorm; Talatrol; THAM; THAM-E; Trimethylolaminomethane; Tris; Tris (buffering agent); Tris buffer; Tris(hydroxymethyl)aminomethane; Tris(hydroxymethyl)methanamine; Tris(hydroxymethyl)methylamine; Tris, free base; Tris-base; Tris-hydroxymethyl-aminomethan [German]; Tris-hydroxymethylaminomethane; Tris-steril; Trisamine; Trisaminol; Trispuffer; Trizma; Trometamol; Trometamolum [INN-Latin]; Tromethamolum; Tromethane; Tutofusin tris; [ChemIDplus] Trimethylol aminomethane; TRIS; [Merck Index] TRIS AMINO; [EPA ChAMP: Submission]


Biological Buffers


Solid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]


Used in chemical manufacturing (surface-active agents, vulcanization accelerators, and pharmaceuticals), as an emulsifying agent (cosmetics, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, and soluble oils), and as an absorbent for acidic gases, biological buffer, acidimetric standard, and therapeutic alkalinizing agent; [Merck Index] Used in buffer systems for the freezer storage of sperm; [REPROTOX] Used in to regulate pH in the transport of live aquatic species, cell culture media, and anti-inflammatory drugs; [EPA ChAMP: Submission]


Not expected to be a skin sensitizer, based on similar compounds; Little if any human toxicity observed in many years of use in drugs and/or personal care products and cosmetics; [EPA ChAMP: Submission] A skin and strong eye irritant; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

2.2E-5 mm Hg

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Related Information in HazMap

Industrial Processes with risk of exposure: