| Agent Name | Phytonadione |
|---|---|
| Alternative Name | Vitamin K1 |
| CAS Number | 84-80-0 |
| Formula | C31-H46-O2 |
| Major Category | Biological Agents |
| Synonyms | 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; Vitamin K 1; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-; 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2',3'-trans-Vitamin K1; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 2-Methyl-3-phytyl-1,4-naphthochinon [German]; 2-Methyl-3-phytyl-1,4-naphthoquinone; 3-Phytylmenadione; Antihemorrhagic vitamin; Aqua mephyton; Aquamephyton; Combinal K1; Fitomenadiona [INN-Spanish]; Fitomenadione [DCIT]; K-Ject; Kativ N; Kephton; Kinadion; Konakion; Mephyton; Mono-Kay; Monodion; Phyllochinon [German]; Phyllochinonum; Phylloquinone; Phytomenadione; Phytomenadionum [INN-Latin]; Phytonadionum; Phytylmenadione; Synthex P; Vitamin K1; Vitamin K1(20); Vitamin k1; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)-; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-; [ChemIDplus] |
| Category | Vitamins and Derivatives |
| Description | Yellow viscous liquid; [Merck Index] Dark yellow or green viscous liquid; [Sigma-Aldrich MSDS] |
| Sources/Uses | The major dietary source of vitamin K found in green plants, algae, and photosynthetic bacteria; Used as a vitamin (prothrombogenic) and veterinary antidote for dicoumarol poisoning; [Merck Index] Essential vitamin for the synthesis of coagulation factors II, VII, IX, and X in the liver; Used to reverse anticoagulation (prolonged prothrombin time) caused by coumarin and indanedione derivatives; [Olson, p. 633] |
| Comments | Reports of allergic contact dermatitis from cosmetic products; "Although the risk for sensitization from cosmetic products containing 1% Vitamin K1 cannot be quantified from the available data, case reports show that Vitamin K1 is a contact allergen in man. In cases of pre-existing sensitization acquired by topical application of Vitamin K1 present in cosmetics, an individual might not be able to receive Vitamin K1 therapeutically or experience allergic reactions upon Vitamin K1 treatment. Therefore, the SCCS considers that vitamin K1 is not safe when used in cosmetic product in a concentration up to 1%." [SCCS (Scientific Committee on Consumer Safety), Opinion on vitamin K1 (phytonadione), 23 March 2010] Severe hypersensitivity reactions have been reported after IV and IM injection; [Olson, p. 633-4] May cause irritation; [Sigma-Aldrich MSDS] |
| Adverse Effects | |
| IARC Carcinogen | Not Classifiable |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Other Information | No other related information on this agent was found. |
Agent Name
Phytonadione
Alternative Name
Vitamin K1
CAS Number
84-80-0
Formula
C31-H46-O2
Major Category
Biological Agents
Synonyms
1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; Vitamin K 1; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-; 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2',3'-trans-Vitamin K1; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 2-Methyl-3-phytyl-1,4-naphthochinon [German]; 2-Methyl-3-phytyl-1,4-naphthoquinone; 3-Phytylmenadione; Antihemorrhagic vitamin; Aqua mephyton; Aquamephyton; Combinal K1; Fitomenadiona [INN-Spanish]; Fitomenadione [DCIT]; K-Ject; Kativ N; Kephton; Kinadion; Konakion; Mephyton; Mono-Kay; Monodion; Phyllochinon [German]; Phyllochinonum; Phylloquinone; Phytomenadione; Phytomenadionum [INN-Latin]; Phytonadionum; Phytylmenadione; Synthex P; Vitamin K1; Vitamin K1(20); Vitamin k1; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)-; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-; [ChemIDplus]
Category
Vitamins and Derivatives
Description
Yellow viscous liquid; [Merck Index] Dark yellow or green viscous liquid; [Sigma-Aldrich MSDS]
Sources/Uses
The major dietary source of vitamin K found in green plants, algae, and photosynthetic bacteria; Used as a vitamin (prothrombogenic) and veterinary antidote for dicoumarol poisoning; [Merck Index] Essential vitamin for the synthesis of coagulation factors II, VII, IX, and X in the liver; Used to reverse anticoagulation (prolonged prothrombin time) caused by coumarin and indanedione derivatives; [Olson, p. 633]
Comments
Reports of allergic contact dermatitis from cosmetic products; "Although the risk for sensitization from cosmetic products containing 1% Vitamin K1 cannot be quantified from the available data, case reports show that Vitamin K1 is a contact allergen in man. In cases of pre-existing sensitization acquired by topical application of Vitamin K1 present in cosmetics, an individual might not be able to receive Vitamin K1 therapeutically or experience allergic reactions upon Vitamin K1 treatment. Therefore, the SCCS considers that vitamin K1 is not safe when used in cosmetic product in a concentration up to 1%." [SCCS (Scientific Committee on Consumer Safety), Opinion on vitamin K1 (phytonadione), 23 March 2010] Severe hypersensitivity reactions have been reported after IV and IM injection; [Olson, p. 633-4] May cause irritation; [Sigma-Aldrich MSDS]
Adverse Effects
IARC Carcinogen
Not Classifiable
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap
Other Information
No other related information on this agent was found.