Agent Name

Phytonadione

Alternative Name

Vitamin K1

CAS Number

84-80-0

Formula

C31-H46-O2

Major Category

Biological Agents

Synonyms

1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; Vitamin K 1; 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, (R-(R*,R*-(E)))-; 1,4-Naphthoquinone, 2-methyl-3-phytyl-; 2',3'-trans-Vitamin K1; 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; 2-Methyl-3-phytyl-1,4-naphthochinon [German]; 2-Methyl-3-phytyl-1,4-naphthoquinone; 3-Phytylmenadione; Antihemorrhagic vitamin; Aqua mephyton; Aquamephyton; Combinal K1; Fitomenadiona [INN-Spanish]; Fitomenadione [DCIT]; K-Ject; Kativ N; Kephton; Kinadion; Konakion; Mephyton; Mono-Kay; Monodion; Phyllochinon [German]; Phyllochinonum; Phylloquinone; Phytomenadione; Phytomenadionum [INN-Latin]; Phytonadionum; Phytylmenadione; Synthex P; Vitamin K1; Vitamin K1(20); Vitamin k1; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl)-; 1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-; [ChemIDplus]

Category

Vitamins and Derivatives

Description

Yellow viscous liquid; [Merck Index] Dark yellow or green viscous liquid; [Sigma-Aldrich MSDS]

Sources/Uses

The major dietary source of vitamin K found in green plants, algae, and photosynthetic bacteria; Used as a vitamin (prothrombogenic) and veterinary antidote for dicoumarol poisoning; [Merck Index] Essential vitamin for the synthesis of coagulation factors II, VII, IX, and X in the liver; Used to reverse anticoagulation (prolonged prothrombin time) caused by coumarin and indanedione derivatives; [Olson, p. 633]

Comments

Reports of allergic contact dermatitis from cosmetic products; "Although the risk for sensitization from cosmetic products containing 1% Vitamin K1 cannot be quantified from the available data, case reports show that Vitamin K1 is a contact allergen in man. In cases of pre-existing sensitization acquired by topical application of Vitamin K1 present in cosmetics, an individual might not be able to receive Vitamin K1 therapeutically or experience allergic reactions upon Vitamin K1 treatment. Therefore, the SCCS considers that vitamin K1 is not safe when used in cosmetic product in a concentration up to 1%." [SCCS (Scientific Committee on Consumer Safety), Opinion on vitamin K1 (phytonadione), 23 March 2010] Severe hypersensitivity reactions have been reported after IV and IM injection; [Olson, p. 633-4] May cause irritation; [Sigma-Aldrich MSDS]

Adverse Effects
IARC Carcinogen

Not Classifiable

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