Agent Name

1,3-Bis(1-isocyanato-1-methylethyl)benzene

CAS Number

2778-42-9

Formula

C14-H16-N2-O2

Major Category

Plastics & Rubber

Synonyms

1,3-Bis(alpha-isocyanatoisopropyl)benzene; Isocyanic acid, m-phenylenediisopropylidene ester; Tetramethyl-m-xylylene diisocyanate; alpha,alpha,alpha',alpha'-Tetramethyl-m-phenylenedimethylene diisocyanate; alpha,alpha,alpha',alpha'-Tetramethyl-m-xylylene diisocyanat; m-Bis(1-isocyanato-1-methylethyl)benzene; m-TMXDI; m-Tetramethylxylene diisocyanate; Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-; Isocyanic acid, alpha,alpha,alpha',alpha'-tetramethyl-m-xylylene ester (8CI); [ChemIDplus] meta-Tetramethylxylene diisocyanate; meta-TMXDI; [HSDB] Isocyanic acid, m-phenylenediiso-propylidene; [EPA ChAMP: Hazard Characterization] 1,3-Bis(1-isocyanato-1-methylethyl)benzol; 1,3-Bis(1-isocianato-1-metiletil)benceno; a,a,a',a'-Tetramethyl-m-xylylene diisocyanate; a,a,a',a'-Tetramethyl-m-phenylenedimethylene diisocyanate; 1,3-Bis(a-isocyanatoisopropyl)benzene; Isocyanic acid, a,a,a',a'-tetramethyl-m-xylylene ester; [EPA ChAMP: IUCLID Data Set] TMXDI (Meta) Aliphatic Isocyanate; [Cytec MSDS] UN2206

Category

Diisocyanates

Description

Clear colorless liquid; [HSDB]

Sources/Uses

Used to make special grades of polyurethane, specialty coatings, aqueous dispersions, automotive coatings and paints, herbicide coatings, inks, sealants, adhesives, thermoplastic urethanes, lacquers, injection moldings, cast elastomers, fabric and leather finishes, adhesives, and wood coatings; [HSDB] Industrial intermediate incorporated into various polymers to improve performance and physical properties; Approved by the FDA for use in food packaging on reaction with certain polyols and polyesters; [EPA ChAMP: IUCLID Data Set]

Comments

Slowly reacts with water; Increased lung weight and histopathological changes of the respiratory tract observed in 13-week vapor inhalation study of rats; Similar findings in 13-week study of mice; Histopathological changes of the lungs observed in 4-week aerosol inhalation study of rats; Repeated dose inhalation studies in rats and mice produced systemic toxicity LOAELs of approximately 4 mg/m3/day for vapor aerosol exposures; [EPA ChAMP: Hazard Characterization] A mild eye and moderate skin irritant; Causes somnolence, dyspnea, and acute and chronic pulmonary edema in inhalation lethal-concentration studies of guinea pigs; Causes cutaneous sensitization, inflammatory effects, and lungs changes, in repeated dose dermal studies of mice; [RTECS]A mild eye and moderate skin irritant; May cause skin sensitization; Irritating vapor; Harmful by inhalation; [Cytec MSDS] See "DIISOCYANATES."

Exposure Assessment
Vapor Pressure

0.0032 mm Hg

Lethal Concentration

LC50 (rat) = 27 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Isocyanates, toxic, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Fibrogenic

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: