Agent Name

Imidazole

CAS Number

288-32-4

Formula

C3-H4-N2

Major Category

Nitrogen Compounds

Synonyms

1,3-Diaza-2,4-cyclopentadiene; 1,3-Diazole; Formamidine, N,N'-vinylene-; Glioksal [Polish]; Glyoxalin; Glyoxaline; IMD; Imidazol; Iminazole; Imutex; Methanimidamide, N,N'-1,2-ethenediyl-; Miazole; Pyrro(b)monazole; 1H-Imidazole; [ChemIDplus] N,N'-Vinylene-formadine; [REPROTOX] UN3263

Category

Imidazoles

Description

Solid; [Merck Index] Colorless to yellow solid with an amine-like odor; [OECD SIDS] White or light yellow crystals; [Sigma-Aldrich MSDS]

Sources/Uses

Used as an intermediate (pharmaceuticals, pesticides, dye intermediates, auxiliaries for textile dyeing and finishing, photographic chemicals, and corrosion inhibitors) and hardener for epoxy resins; Also used in process regulators, anti-freeze agents, photographic applications, laboratory applications, glues/adhesives, cement fillers or sealing compounds, paints, varnishes, lacquers, consumer cleaning and washing agents, swimming pool applications, and in publishing, printing, and reproduction of recorded media; [OECD SIDS]

Comments

Corrosive to skin and irritating to eyes in rabbits--may cause permanent eye injury; A 90-day oral study of rats showed histopathological changes of the liver and kidney at 180 mg/kg/day; No evidence of neurotoxicity; No effects on sperm parameters or toxicity to male or female reproductive organs observed in the 90-day study; Teratogenicity and developmental toxicity observed at doses maternally toxic in rats; [OECD SIDS] No increase in abnormalities of offspring in rats dosed 240 mg/kg by gavage during embryogenesis (non-standard study, no information on maternal toxicity); [REPROTOX] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; May be toxic to human reproduction and cause harm to the unborn child; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

0.002 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Corrosive solid, basic, organic, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: