Agent Name

Citronellol

CAS Number

106-22-9

Formula

C10-H20-O

Major Category

Biological Agents

Synonyms

6-Octen-1-ol, 3,7-dimethyl-; 2,6-Dimethyl-2-octen-8-ol; 3,7-Dimethyl-6-octen-1-ol; Cephrol; Citronellol (ex. Java citronella oil) (natural); Citronellol (natural); Rodinol; beta-Citronellol; [ChemIDplus]

Category

Plant Oils and Extracts

Description

Colorless to pale yellow liquid with a sweet floral odor; [ToxPlanet: EPA BRADs] Colorless liquid with a rose-like odor; [Acros Organics MSDS]

Sources/Uses

l-Form: in rose and geranium oils; d-Form: in Ceylon and Java citronella oils; Used in perfumery; [Merck Index] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Present in over 30 essential oils, fruits, edible plants, wine, beer, and black tea; Active ingredient in pesticide used to control mites on agricultural crops, ornamentals, and landscapes; Also extensively used as fragrance (detergents, soaps, lotions, perfumes, etc.), as a flavoring agent, and component of citronella oil (used in candles, sprays, oils, and insect repellents); [ToxPlanet: EPA BRADs]

Comments

Causes degenerative changes to brain, dermatitis, changes in liver and kidney weights, and somnolence in acute oral studies of rats; Causes alteration of classical conditioning and abnormal liver function tests in 100-day inhalation studies of rats; [RTECS] A moderate skin irritant; Category members and supporting chemicals demonstrate skin sensitization in humans and mice; No systemic toxicity in 112-day and 17-week oral studies of rats at the highest tested doses (approximately 500 mg/kg/day); Mortality, stomach lesions, and cytoplasmic vacuolization (lipidosis) of the liver, kidney, and myocardium in 13-week oral study of mice (LOAEL of 2,000 mg/kg/day); [Reference #1] Fragrance ingredient that is a recognized contact allergen in consumers; [ToxPlanet: EC: SCCNFP] Generally regarded as safe (GRAS) by the FDA; [ToxPlanet: EPA BRADs] Safe when used as a flavoring agent in food; [JECFA] An irritant; [Acros Organics MSDS]

Reference Link

EPA ChAMP: Terpenoid Primary Alcohols and Related Esters - 2009

Exposure Assessment
Vapor Pressure

0.04 mm Hg

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: