Agent Name

3,4,5,3',4'-Pentachlorobiphenyl

CAS Number

57465-28-8

Formula

C12-H5-Cl5

Major Category

Other Classes

Synonyms

3,3',4,4',5-Pentachloro-1,1'-biphenyl; 3,3',4,4',5-Pentachlorobiphenyl; 3,4,3',4',5'-Pentachlorobiphenyl; 3,4,5,3',4'-Penta coplanar polychlorinated biphenyl; PCB 126; 1,1'-Biphenyl, 3,3',4,4',5-pentachloro-; [ChemIDplus] UN3432

Category

Halogenated Polyaromatics

Description

White solid; [Cerilliant MSDS]

Comments

Clear evidence of carcinogenicity in female rats; [NTP] Classified as Group 1 based on animal evidence and mechanistic data (strong evidence for an aryl hydrocarbon receptor) without epidemiological evidence; [IARC 2012] May have cumulative adverse effects; Targets the liver, kidney, CNS, and skin; [Cerilliant MSDS] For IARC changes in 2016, see "Polychlorinated biphenyls" and the linked occupational disease.

Reference Link

IARC 2012: PCB 126

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Known Carcinogen

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: