Agent Name

Dipropylene glycol monoethyl ether

Alternative Name

DPGEE

CAS Number

30025-38-8

Formula

C8-H18-O3

Major Category

Solvents

Synonyms

DPGEE; [Glycol Ethers Online] Propanol, (2-ethoxymethylethoxy)-; [ChemIDplus] Propanol, 2-ethoxy-methylethoxy; [ToxPlanet: ECETOC]

Category

Glycol Ethers (P Series)

Sources/Uses

Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

Comments

A mild eye irritant in rabbits; Not a skin sensitizer in guinea pigs using the Magnusson and Kligman method; Exposure to saturated vapor concentration (estimated at 2,410 mg/m3) for 7 hours resulted in eye and nasal irritation, transient weight loss, and mortality in 1 of 12 rats exposed; Survivors recovered fully in 24 hours; Increased liver weights without corresponding histopathology and minimal to minor hyaline droplet formation in the proximal tubular cells in kidneys of males observed in 4-week oral study of rats at 1,000 mg/kg/day; Increased liver and kidney (males) weights with histopathological changes observed in 13-week oral study of rats at 250 and 1,000 mg/kg/day; No effects noted in the functional observation batteries or on hematological parameters; A 1-generation study of rats produced NOAELs for parents and reproductive toxicity of the highest tested dose (1,000 mg/kg/day); Single oral doses of 4.7 mg/kg caused symptoms consistent with CNS depression in rats; [ToxPlanet: ECETOC]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: