Agent Name

Vitamin A

Alternative Name

Retinol

CAS Number

68-26-8

Formula

C20-H30-O

Major Category

Biological Agents

Synonyms

(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 2,4,6,8-Nonatetraen-1-ol, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-; A-Mulsal; A-Sol; A-Vi-Pel; A-Vitan; ACON; ATAV; Afaxin; Agiolan; Agoncal; Alcovit A; all-trans Retinol; Alphalin; Alphasterol; Anatola; Anatola A; Anti-Infective vitamin; Antixerophthalmic vitamin; Antixerophthalmisches Vitamin; Aoral; Apexol; Apostavit; Aquasol A; Aquasynth; Atars; Avibon; Avita; Avitol; Axerol; Axerophthol; Axerophtholum; Bentavit A; Biosterol; Chocola A; Del-VI-A; Disatabs Tabs; Dofsol; Dohyfral A; Epiteliol; Hi-A-Vita; Homagenets Aoral; Lard Factor; Myvpack; Nio-A-Let; Oleovitamin A; Ophthalamin; Plivit A; Prepalin; Retinol; Retinol, all trans-; Retinolo [DCIT]; Retinolum [INN-Latin]; Retrovitamin A; Sehkraft A; Solu-A; Super A; Testavol; Testavol S; Vaflol; Vafol; Veroftal; Vi-Dom-A; Vi-Alpha; Vio-A; Vitamin A alcohol; Vitamin A alcohol (VAN); Vitamin A alcohol, all-trans-; Vitamin A1; Vitamin A1 alcohol; Vitamin A1 alcohol, all trans; Vitamin A1, all-trans-; Vitamine A; Vitaminum A; Vitavel-A; Vitpex; Vogan; Vogan-Neu; Wachstumsvitamin; all-trans-Retinol; all-trans-Retinyl alcohol; all-trans-Vitamin A; all-trans-Vitamin A alcohol; Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol; [ChemIDplus]

Category

Vitamins and Derivatives

Description

Solid; [Merck Index] Yellow or orange solid; [NTP]

Sources/Uses

Essential micronutrient found in animals; [Merck Index] Used as a nutritional supplement for foods; [FDA] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] "Retinol is one of the animal forms of vitamin A. It is a diterpenoid and an alcohol. It is convertible to other forms of vitamin A, and the retinyl ester derivative of the alcohol serves as the storage form of the vitamin in animals." [Wikipedia]

Comments

Oral administration of high doses in adults causes cirrhosis, hemorrhage, anorexia, jaundice, and dermatitis; [RTECS] Contraindicated in pregnancy at doses > FDA RDA; May be toxic if more than 25,000 IU/d consumed for longer that 2-3 weeks; Toxic effects include liver injury and increased intracranial pressure (blurred vision, headaches, and altered mental status); Serum levels may be useful in diagnosis; [Olson, p. 69, 446] An irritant; Harmful by ingestion; Teratogenic effects observed in experimental animals; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

7.5E-8 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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