Agent Name

Phenylglycine acid chloride hydrochloride

CAS Number

39878-87-0

Formula

C8-H8-Cl-N-O.Cl-H

Major Category

Other Uses

Synonyms

(-)-alpha-(Chloroformyl)benzylammonium chloride; Benzeneacetyl chloride, alpha-amino-, hydrochloride (1:1),(alphaR)-; Benzeneacetyl chloride, alpha-amino-, hydrochloride,(alphaR)-; (R)-alpha-Aminobenzeneacetyl chloride, hydrochloride; D-(-)-Phenylglycine acid chloride, hydrochloride; [ChemIDplus] (R)-(-)-2-Phenylglycine chloride hydrochloride; D-(-)-alpha-Phenylglycine chloride hydrochloride; [Sigma-Aldrich MSDS] UN3261

Category

Pharmaceuticals

Description

Solid; Readily hydrolyzes in water to D-phenylglycine; [IUCLID] Light brown powder; [Sigma-Aldrich MSDS]

Sources/Uses

An intermediate in the production of ampicillin; [Reference #1]

Comments

Corrosive to skin (rabbit); EC classification: not irritating; Risk of serious damage to eyes; Skin and respiratory sensitization reported in humans; [IUCLID] Occupational asthma confirmed in 29% of pharmaceutical workers; [Malo] Causes burns and lachrymation; Inhalation may cause corrosive injuries to upper respiratory tract; [Sigma-Aldrich MSDS] See "Ampicillin."

Reference Link

Hypersensitivity to phenylglycine acid chloride.

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Corrosive solid, acidic, organic, n.o.s."

Adverse Effects
Asthma

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: