Agent Name

1,3-Diisopropylcarbodiimide

CAS Number

693-13-0

Formula

C7-H14-N2

Major Category

Nitrogen Compounds

Synonyms

Diisopropylcarbodiimide; N,N'-Diisopropylcarbodiimide; N,N'-Methanetetraylbis-2-propanamine; 2-Propanamine, N,N'-methanetetraylbis-; Carbodiimide, diisopropyl-; N,N'-Methanetetraylbis(1-methylethylamine); [ChemIDplus] DIPC; DIC; [Merck Index] UN2929

Category

Other Nitrogen Compounds

Description

Colorless liquid; [Merck Index]

Sources/Uses

Used as a reagent in synthetic organic chemistry; [Merck Index] Used as a chemical intermediate and as a stabilizer for Sarin (chemical weapon); [HSDB]

Comments

An irritant; May cause skin and respiratory sensitization; [Merck Index] No evidence of carcinogenicity in dermal studies of mice and rats; Clinical and histological evidence of neurotoxicity observed in male rats; [NTP] A mild skin irritant; Causes cutaneous sensitization, convulsions, coma, lachrymation, ataxia, changes in thymus and kidney weights, weight loss, spermatogenesis, and allergic dermatitis in repeated-dose dermal studies of mice; [RTECS] Reacts with water producing 1,3-diisopropylurea; [HSDB] An irritant that may cause serious eye injury; May cause skin and respiratory sensitization; Highly toxic by inhalation; [Alfa Aesar MSDS]

Exposure Assessment
TIH

Yes

Vapor Pressure

9.79 mm Hg

Lethal Concentration

LC50 (rat) = 105 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic liquid, flammable, organic, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: