Agent Name

1-Naphthylisothiocyanate

CAS Number

551-06-4

Formula

C11-H7-N-S

Major Category

Nitrogen Compounds

Synonyms

1-Isothiocyanate-naphthalene; 1-Isothiocyanatonaphthalene; 1-Naftylisothiokyanat [Czech]; 1-Naphthyl isothiocyanate; alpha-Naphthyl isothiocyanate; ANI; ANIT; Kesscocide; Naphthalene, isothiocyanato-; Isothiocyanic acid, 1-naphthyl ester; Naphthalene, 1-isothiocyanato-; [ChemIDplus] alpha-Naphthyl mustard oil; alpha-Naphthylisothiocyanate; Isothiocyanatonaphthalene; 1-Naphthyl ester isothiocyanic acid; [CAMEO] UN2811

Category

Isothiocyanates

Description

White nearly odorless solid; [Merck Index] Slightly yellow odorless powder; [Acros Organics MSDS]

Sources/Uses

"A tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function. It may cause skin and kidney damage." [ChemIDplus] Has been used as an insecticide (with pyrethrum); [NTP]

Comments

Causes abnormal liver function tests, cholestatic jaundice, and hepatitis in acute oral studies of rats; [RTECS] A hepatotoxin; [Merck Index] Slowly hydrolyzed by water; [CAMEO] May cause liver and kidney injury; [NTP] May cause irritation; Harmful by ingestion; May cause liver injury; [Acros Organics MSDS] See "Phenyl isothiocyanate."

Exposure Assessment
Vapor Pressure

0.000132 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, organic, n.o.s."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: