Agent Name

Isatin

CAS Number

91-56-5

Formula

C8-H5-N-O2

Major Category

Nitrogen Compounds

Synonyms

2,3-Diketoindoline; 2,3-Dioxo-2,3-dihydroindole; 2,3-Dioxoindoline; 2,3-Indolinedione; Isatic acid lactam; Isatine; Isatinic acid anhydride; Isotin; o-Aminobenzoylformic anhydride; Pseudoisatin; 1H-Indole-2,3-dione; Indole-2,3-dione; Indoline-2,3-dione; [ChemIDplus] Indolinedione-2,3; [ToxPlanet: EC: SCCP]

Category

Indoles

Description

Orange solid; [Merck Index] Orange odorless powder; [Alfa Aesar MSDS]

Sources/Uses

Used to make vat dyes and in analytical chemistry as a reagent for cuprous ions, mercaptans, thiophene, and indican; [Merck Index] Used in hair coloring products; [ToxPlanet: EC: SCCP]

Comments

Not a skin or eye irritant in rabbits; A very potent skin sensitizer in guinea pig maximization study; No evidence of contact allergy in Buehler study of guinea pigs (considered inconclusive due to orange/red staining at application sites); Delayed contact hypersensitivity observed in local lymph node assay (LLNA) studies of mice; Teratogenicity observed in the presence of maternal toxicity in rats; [ToxPlanet: EC: SCCP] Causes flaccid paralysis without anesthesia (usually neuromuscular blockage) and changes in motor activity in oral and intravenous lethal-dose studies of rats; Causes pigmented or nucleated red blood cells and changes in erythrocyte count in 6-week oral studies of rats; [RTECS] May cause eye irritation; Reproductive effects observed in experimental animals; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

1.11E-5 mm Hg

Lethal Concentration

LC50 (rat) > 5,200 mg/m3/4hr

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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