Agent Name

2,4-Di-tert-butylphenol

CAS Number

96-76-4

Formula

C14-H22-O

Major Category

Other Classes

Synonyms

1-Hydroxy-2,4-di-tert-butylbenzene; Antioxidant No. 33; Phenol, 2,4-di(1,1-dimethylethyl)-; Prodox 146; Prodox 146A-85X; Phenol, 2,4-bis(1,1-dimethylethyl)-; Phenol, 2,4-di-tert-butyl-; [ChemIDplus] 2,4-Bis(1,1-dimethylethyl)phenol; 2,4-Bis(1,1-dimetiletil)fenolo; 2,4-Bis(tert-butyl)phenol; 2,4-Di-tert-butylhydroxybenzene; [IUCLID] UN2430

Category

Phenols

Description

Solid; [EPA ChAMP: Hazard Characterization] Yellow or white crystalline solid; [Sigma-Aldrich MSDS]

Sources/Uses

Used as an antioxidant; [REPROTOX] Used in the chemical and fuel industries; Used as an intermediate and stabilizer; [IUCLID] Used to make phenolic antioxidants and UV stabilizers; [ToxPlanet: CPS&Q - Summary Fact Sheet] Used as a stabilizer in manufacture and formulation, fuel additive, and intermediate; [ToxPlanet: ECHA REACH Registrations]

Comments

Di- and tri-substituted mixed alkylphenols: Category members demonstrate moderate skin irritation; Low acute oral and moderate acute dermal toxicity; Evidence of liver toxicity in repeated-dose oral studies of rats; Developmental toxicity at doses producing marginal systemic toxicity in adults; No evidence of reproductive toxicity, mutagenicity, or carcinogenicity; [EPA ChAMP: Hazard Characterization] Reported oral LD50 (rat) values of 3,250 and 1,300 mg/kg; A skin and eye irritant in rabbits; Not a skin sensitizer in guinea pig maximization test; Identified in samples of rubber most often used by employees in hydraulic pump manufacturing diagnosed with cutaneous depigmentation (vitiligo); [IUCLID] Histopathological changes of the liver and kidney observed in 28-day oral study of rats; NOEL's of 75 mg/kg/day in males and 20 mg/kg/day in females; [ToxPlanet: JECDB] An irritant that may cause serious eye injury; [Sigma-Aldrich MSDS] See "Clorophene."

Exposure Assessment
Vapor Pressure

0.0075 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Alkyl phenols, solid, n.o.s. (including C2-C12 homologues)."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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