Agent Name

2,6-Diaminopyridine

CAS Number

141-86-6

Formula

C5-H7-N3

Major Category

Nitrogen Compounds

Synonyms

DAP; DAP (amine); 2,6-Pyridinediamine; Pyridine, 2,6-diamino-; Pyridine-2,6-diyldiamine; [ChemIDplus] Pyridine-2,6-diamine; [ToxPlanet: EC: SCCS - Opinion] 2,6-DAP; [NTP] UN2671

Category

Pyridines

Description

Slightly brown solid; [ToxPlanet: EC: SCCS - Opinion] Light brown, yellow, or off-white powder or flakes; [Alfa Aesar MSDS]

Sources/Uses

Used in oxidative hair dyes; [ToxPlanet: EC: SCCS - Opinion] Used as an intermediate for pharmaceuticals and polyamides, epoxy curing agent, and coupler in hair dyes; [NTP]

Comments

One report of occupational contact dermatitis in the pharmaceutical industry; [NTP] A strong sensitizer based on the mouse local lymph node assay (LLNA); Oral LD50 (rat) = 50-300 mg/kg; A 90-day oral study of rats demonstrated the erythrocytes, spleen, kidney, and liver as target organs of toxicity (most changes recovering after 4-week recovery period); Developmental toxicity (decreased fetal and placental weights and incomplete thoracic vertebrae ossification) but no teratogenicity observed in oral study of rats in the presence of maternal toxicity; [ToxPlanet: EC: SCCS - Opinion] An irritant; Toxic by ingestion; [Alfa Aesar MSDS]

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Aminopyridines."

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: