Agent Name

2-Ethylhexyl nitrate

CAS Number




Major Category

Nitrogen Compounds


Ethylhexyl nitrate; Nitronal; Nitric acid, 2-ethylhexyl ester; [ChemIDplus] "Ethyl" Diesel Ignition Improver 3 ("Ethyl" DII-3); 2-EHN; 3-Nitro-oxymethylheptane; Du Pont Diesel Additive 1000; DU PONT DIESEL ADDITIVE 1000; ECA 8478; ETHYL DII-3; Exchem GO-1 Cetane Improver; EXCHEM GO-1 CETANE IMPROVER; EXXON ECA 8478; HITEC 4103; HiTec 4103 Fuel Additive; NEH; NITRATE D'ETHYL-2 HEXYLE; Nitric acid, 2-ethylhexyl ester of; NITRIC ACID, 2-ETHYLHEXYL ESTER; Octel CI-0801 Cetane Number Improver; OCTEL CI-0801 CETANE NUMBER IMPROVER; OCTYL NITRATE; PROCETANE; [IUCLID] UN1993


Nitrates and Nitrites


Light yellow liquid with a pleasant odor; [CAMEO] Colorless liquid; [Sigma-Aldrich MSDS]


Used in chemical manufacture; [CAMEO] Used as a diesel fuel additive and solvent; [REPROTOX] Used as an additive in diesel fuels to improve ignition and raise the cetane number; [EPA ChAMP: Submission]


Can cause headaches from dermal or inhalation exposure; [IUCLID] Causes little or no eye irritation in rabbits; Not a skin sensitizer in guinea pig maximization tests; Increased mean liver weight and polycythemia observed in 14-day inhalation study of rats at concentrations greater than 42 ppm; [IUCLID] Irritation but no systemic toxicity observed in 21-day dermal study of rabbits at doses up to 500 mg/kg/day; A 28-day oral study of rats produced changes in urinary parameters, significantly increased liver and kidney weights, and a NOEL of 20 mg/kg/day; [EPA ChAMP: Submission] May cause irritation; Harmful by ingestion, inhalation, and skin absorption; [Sigma-Aldrich MSDS] See "Amyl nitrate."

Exposure Assessment
Vapor Pressure

0.03 mm Hg

Lethal Concentration

LC50 (rat) > 14,000 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Combustible liquid, n.o.s."

Adverse Effects

Methemoglobinemia, Secondary

Links to Other NLM Databases
Toxicity Information


Chemical Information

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Other Information

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