Agent Name

alpha-Ketobutyric acid

CAS Number

600-18-0

Formula

C4-H6-O3

Major Category

Biological Agents

Synonyms

2-Oxobutanoic acid; 2-Oxobutyric acid; 3-Methylpyruvic acid; alpha-Oxo-n-butyric acid; alpha-Oxobutyrate; Butanoic acid, 2-oxo-; Butyric acid, 2-oxo-; Formic acid, propionyl-; Ketobutyrate; Pyruvic acid, methyl-; 2-Ketobutyric acid; [ChemIDplus]

Category

Amino Acids and Derivatives

Description

Colorless hygroscopic paste; mp = 32-34 deg C; [Acros Organics MSDS]

Sources/Uses

Used as a flavoring agent; [FDA] "alpha-Ketobutyric acid is a product of the lysis of cystathionine. It is also one of the degradation products of threonine, produced by the catabolism of the amino acid by threonine dehydratase. It is also produced by the degradation of homocysteine and the metabolism of methionine. Alpha-Ketobutyric acid is transported into the mitochondrial matrix, where it is converted to propionyl-CoA by Branched-chain alpha-keto acid dehydrogenase complex. Further mitochondrial reactions produce succinyl CoA." [Wikipedia]

Comments

Safe when used as a flavoring agent in food; [JECFA] An irritant; May cause CNS depression; [Acros Organics MSDS]

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