Agent Name

3,5-Xylidine

Alternative Name

3,5-Dimethylaniline

CAS Number

108-69-0

Formula

C8-H11-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-3,5-dimethylbenzene; 3,5-Dimethylaniline; 3,5-Dimethylbenzenamine; 3,5-Dimethylbenzeneamine; 3,5-Dimethylphenylamine; 3,5-Xylylamine; 5-Amino-1,3-dimethylbenzene; 5-Amino-1,3-xylene; Benzene, 1-amino-3,5-dimethyl-; Benzenamine, 3,5-dimethyl-; [ChemIDplus] 5-Amino-m-xylene; [ICSC] 3,5-Dimethyl-1-aminobenzene; m-Xylidine; [CAMEO] 3,5-DMA; [NTP] UN1711

Category

Amines, Aromatic

Description

Clear light yellow liquid; Turned reddish to brown by air; mp = 9.8 deg C; [ICSC] Light brown liquid; [Alfa Aesar MSDS]

Sources/Uses

Used mainly in dye manufacture; Also used as reagents in synthetic organic chemistry; [Merck Index] Used to make pharmaceuticals, azo dyes, curing agents, antioxidants, antiozonants, additives and detergents for gasoline, wood preservatives, wetting agents for textiles, frothing agents for ore dressing, special lacquers, and metal complexers; [NTP] Used to make fine chemicals; [ToxPlanet: ECHA REACH Registrations]

Comments

Heavy exposure can cause methemoglobinemia and lowering of consciousness; Chronic exposure may cause anemia; Can be absorbed through skin; [ICSC] Erythrocyte hemolysis, significantly increased methemoglobin levels, and liver and kidney injury observed in sub-chronic oral studies of rats; May cause irritation, headache, drowsiness, cyanosis, confusion, convulsions, and other nervous system and blood effects; [NTP] Toxic by ingestion, inhalation, and skin absorption; Prolonged or repeated exposure may cause kidney and liver injury; [ToxPlanet: ECHA REACH Registrations] An irritant; Toxic by ingestion, inhalation, and skin absorption; May induce methemoglobinemia; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.5 ppm, inhalable fraction and vapor

PEL (OSHA)

5 ppm

IDLH (NIOSH)

50 ppm

Vapor Pressure

0.12 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Xylidines."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.