Agent Name

5-Bromouracil

CAS Number

51-20-7

Formula

C4-H3-Br-N2-O2

Major Category

Biological Agents

Synonyms

5-Bromo-2,4(1H,3H)-pyrimidinedione; 5-BrU; 5-BU; Bromouracil; 2,4(1H,3H)-Pyrimidinedione, 5-bromo-; Uracil, 5-bromo-; [ChemIDplus] 5-Bromo-2,4-dihydroxypyrimidine; 5-Bromo-2,4-pyrimidinedione; [CAMEO]

Category

Nucleic Acids and Derivatives

Description

Solid; [Merck Index] White to off-white powder; [Acros Organics MSDS]

Sources/Uses

Used as an experimental mutagen; Alters DNA base-pair sequences by replacing thymine; [Merck Index]

Comments

Causes somnolence, muscle weakness, and dyspnea in intraperitoneal lethal-dose studies of mice (LD50 = 1,400 mg/kg); [RTECS] May cause irritation; Harmful by ingestion; Risk of irreversible adverse health effects; [Acros Organics MSDS] See "Uracil."

Exposure Assessment
Vapor Pressure

2.27E-7 mm Hg

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.