Agent Name

Enflurane

CAS Number

13838-16-9

Formula

C3-H2-Cl-F5-O

Major Category

Other Uses

Synonyms

(+-)-2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; Anesthetic 347; Anesthetic Compound No. 347; C 347; Compound 347; Efrane; Enflurane; Enflurano [INN-Spanish]; Enfluranum [INN-Latin]; Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-; Ethane, 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoro-, (+-)-; Ethrane; Methylflurether; OHIO 347; [ChemIDplus]

Category

Waste Anesthetic Gases

Description

Clear, colorless liquid with a mild, sweet odor; inhalation anesthetic; [NIOSH]

Sources/Uses

Stable inhalation anesthetic; [ChemIDplus]

Comments

See "WASTE ANESTHETIC GASES" Enflurane is in the list of "Some volatile substances which may be abused by inhalation" published on the web site of the U.N. International Drug Control Programme, indicating its potential to cause narcosis in workers. [Reference #1] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC] Occupational asthma confirmed in a hospital worker; [Malo]

Reference Link

Volatile Substance Abuse

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

75 ppm

MAK

20 ppm

Vapor Pressure

591 mm Hg

Lethal Concentration

LC50 (rat) = 14,000 ppm/3h

Reference Link

Delayed asthmatic response following occupational exposure to enflurane.

Adverse Effects
Asthma

Yes

Neurotoxin

CNS Solvent Syndrome

Reproductive Toxin

Yes

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: