Agent Name

Berberine

CAS Number

2086-83-1

Formula

C20-H18-N-O4

Major Category

Other Uses

Synonyms

9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Berberin; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; Berbinium, 7,8,13,13a-tetrahydro-9,10-dimethoxy-2,3-(methylenedioxy)-; [ChemIDplus] 5,6-Dihydro-9,10-dimethoxybenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; 7,8,13,13a-Tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; Umbellatine; [Merck Index]

Category

Biochemical Research

Description

Yellow solid; [Merck Index]

Sources/Uses

Occurs naturally in many plants and used in traditional medicine as an antiprotozoal, antimalarial, antibacterial, and antidiarrheal; [Merck Index] "Berberine prevents and suppresses proinflammatory cytokines, E-selectin, and genes, and increases adiponectin expression which partly explains its versatile health effects. Berberine is a nucleic acid-binding isoquinoline alkaloid with wide potential therapeutic properties." [Wikipedia]

Comments

Decreased fetal weight (attributed to changes in maternal weight) but no teratogenicity observed in mice and rats; [REPROTOX]

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