Agent Name

Podofilox

CAS Number

518-28-5

Formula

C22-H22-O8

Major Category

Other Uses

Synonyms

(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one; Condylox; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; 5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,; (5R-(5alpha,5abeta,8aalpha,9alpha))-; Podofilox; Podophyllinic acid lactone; Podophyllotoxin; Podophyllotoxin 7; [ChemIDplus]

Category

Pharmaceuticals

Description

Light-brown to greenish-yellow powder; Commercial resin preparations contain 5-25% podophyllum. [INCHEM]

Sources/Uses

Used in the treatment of warts and corns; [INCHEM] "Podophyllotoxin, otherwise known as podofilox is a non-alkaloid toxin in the lignin family present at concentrations of 0.3 to 1.0% by mass in the rhizome of American Mayapple Podophyllum peltatum. . . . Podophyllotoxin is the pharmacological base for the important anti-cancer drug Etoposide." [Wikipedia]

Comments

"The main active constituent of the resin from the roots of may apple or mandrake (Podophyllum peltatum and P. emodi). It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives." [ChemIDplus]

Reference Link

INCHEM: Podophyllum

Exposure Assessment
Vapor Pressure

8.34E-15 mm Hg

Explanatory Notes

Melting point = 114-118 deg C; [INCHEM]

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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