Agent Name

Quinuclidinyl benzilate

CAS Number

6581-06-2

Formula

C21-H23-N-O3

Major Category

Toxic Gases & Vapors

Synonyms

3-(2,2-Diphenyl-2-hydroxyethanoyloxy)-quinuclidine; 3-Chinuclidylbenzilate; 3-Quinuclidinol benzilate; 3-Quinuclidinyl benzilate; 3-Quinuclidyl benzilate; BZ; QNB; Ro 2-3308; [ChemIDplus]

Category

Chemical Weapons

Description

Crystals; [Sax] Odorless and nonirritating; [USAMRICD, p. 141]

Sources/Uses

"A High-affinity muscarinic antagonist commonly used as a tool in animal and tissue studies." [ChemIDplus]

Comments

BZ was developed as a chemical weapon in the 1960s. The same or similar compound (Agent 15) was detected in Iraqi stockpiles in 1998. BZ poisoning is manifested as the anticholinergic toxidrome, similar to poisoning by Jimson weed and many anticholinergic drugs (atropine, oxybutynin, scopolamine, antihistamines, etc.). BZ is an odorless and nonirritating solid that is soluble in propylene glycol and DMSO. Inhalation of aerosol is the most likely route of exposure, but it is also toxic after ingestion or skin absorption. Adverse effects are peripheral (red as a beet, dry as a bone, hot as a hare, blind as a bat) and central (mad as a hatter). Victims may have hallucinations, mumbling speech, and peculiar "woolgathering" movements of the hands. The two greatest risks to patients are 1.) injuries secondary to the intoxicated state and erratic behavior; and 2.) hyperthermia. [USAMRICD, p. 136-160]

Exposure Assessment
Explanatory Notes

mp = 164-5 deg C; [Sax]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.