Agent Name

Dimethyl fumarate

CAS Number

624-49-7

Formula

C6-H8-O4

Major Category

Other Classes

Synonyms

2-Butenedioic acid, dimethyl ester, (E)-; Allomaleic acid dimethyl ester; BG 00012; BG 12 compound; BG 12 [Fumarate]; BG-00012; BG-12; BG-12 [Fumarate]; BG00012; Boletic acid dimethyl ester; Dimethyl trans-ethylenedicarboxylate; Dimethylester kyseliny fumarove [Czech]; Dimethylfumarate; Ethylene, 1,2-bis(methoxycarbonyl)-, trans-; FAG 201; FAG201; Fumaderm; Fumaric acid, dimethyl ester; Methyl fumarate; Tecfidera; TL 353; trans-1,2-Ethylenedicarboxylic acid dimethyl ester; trans-Butenedioic acid dimethyl ester; 2-Butenedioic acid (2E)-, 1,4-dimethyl ester; 2-Butenedioic acid (2E)-, dimethyl ester; 2-Butenedioic acid (E)-, dimethyl ester; [ChemIDplus] Dimethyl (2E)-but-2-enedioate; DMFu; Dimethyl (E)-butenedioate; [ToxPlanet: ECHA - Annex XV Restriction Report]

Category

Esters, Other

Description

Solid; [HSDB] Off-white crystalline solid; [Sigma-Aldrich MSDS]

Sources/Uses

Used to treat psoriasis and multiple sclerosis; [REPROTOX] Used to make products with formyl derivatives; [HSDB] Used as a product preservative; [ToxPlanet: ECHA - Annex XV Restriction Report] Used in Asia as a wide-spectrum biocide; [Kanerva, p. 1786]

Comments

A severe eye and moderate skin irritant; [RTECS] Irritating to skin and eyes; [HSDB] Considered a skin sensitizer in humans; [ToxPlanet: ECHA - RAC] A skin and strong eye irritant; May cause skin sensitization; Harmful by skin absorption; [Sigma-Aldrich MSDS] See "Fumaric acid."

Restricted

Use restricted to concentrations of 0.1 mg/kg; [ToxPlanet: ECHA - RAC]

Reference Link

The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer.

Exposure Assessment
Vapor Pressure

3.83 mm Hg

Lethal Concentration

LC (mouse) > 3,100 mg/m3/10min

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: