Agent Name

Methyl (E)-crotonate

CAS Number

623-43-8

Formula

C5-H8-O2

Major Category

Other Classes

Synonyms

(E)-2-Butenoic acid methyl ester; (E)-Crotonic acid methyl ester; Methyl (E)-2-butenoate; Methyl E-crotonate; Methyl E-Propene-1-carboxylate; Methyl trans-2-butenoate; Methyl trans-crotonate; trans-2-Butenoic acid methyl ester; 2-Butenoic acid, methyl ester, (2E)-; 2-Butenoic acid, methyl ester, (E)-; Crotonic acid, methyl ester, (E)-; [ChemIDplus] UN3272

Category

Esters, Other

Description

Colorless liquid; [Alfa Aesar MSDS]

Comments

A moderate skin and mild eye irritant in rabbits; [ToxPlanet: EC: SCCNFP] Human volunteers tested with 6% in petrolatum demonstrated no irritation following 48-hour closed-patch test and sensitization reactions in 2 of 25 subjects; [ToxPlanet: EC: SCCNFP] Safe when used as a flavoring agent in food; [ToxPlanet: EFSA] A skin, respiratory tract, and strong eye irritant; [Alfa Aesar MSDS] Search for (623-43-8[EC/RN Number]) AND (allergic OR dermatitis OR sensitizer OR sensitization): no results; [PubMed]

Restricted

Prohibited for use as a fragrance due to sensitizing potential; [ToxPlanet: EC: SCCNFP]

Exposure Assessment
Lethal Concentration

LC (rat) > 19,000 ppm/6hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Esters, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: