Agent Name

1,2-Dichloroethylene, all isomers

Alternative Name

Acetylene dichloride

CAS Number

540-59-0; 156-59-2; 156-60-5

Formula

C2-H2-Cl2

Major Category

Solvents

Synonyms

cis-Acetylene dichloride; trans-Acetylene dichloride; sym-Dichloroethylene; [NIOSH] 1,2-Dichloroethene; Dioform; [ChemIDplus] UN1150

Category

Chlorinated Aliphatics

Description

Colorless liquid (usually a mixture of the cis & trans isomers) with a slightly acrid, chloroform-like odor; [NIOSH]

Sources/Uses

Used as a solvent and chemical intermediate; [ACGIH] Used as a refrigerant, degreaser, dry cleaning agent, and solvent for perfumes, adhesives, lacquers, oils, and resins; [HSDB] Only the trans isomer is commercially available in the US--used for precision cleaning of electronic components and a small amount used as a blowing agent for specialty foams; [EPA Toxicological Review, 2010]

Comments

Liver injury observed in acute animal toxicology studies; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; [ICSC]1,2-Dichloroethylene (UN1150) has warning of explosive polymerization; [ERG 2016] See "trans-1,2-Dichloroethylene" and "cis-1,2-Dichloroethylene."

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

200 ppm

PEL (OSHA)

200 ppm

MAK

200 ppm

IDLH (NIOSH)

1000 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Patty [1963] reported that rats exposed to the cisisomer of dichloroethylene for 4 hours at 8,000 ppm were neither killed nor anesthetized, but at 16,000 ppm, anesthesia occurred in 8 minutes and death occurred in 4 hours [Smyth 1956]. Because Patty [1963] also reported that the transisomer was twice as toxic an anesthetic as the cisisomer, an IDLH of 4,000 ppm is chosen. . . . Human data: It has been reported that exposure to the transisomer at 2,200 ppm caused burning of the eyes, vertigo, and nausea [von Oettingen 1955]. An exposure to the transisomer at 819 ppm for 30 minutes has been reported to cause no untoward effects, while inhalation of either 1,687 to 2,184 ppm for 5 minutes or 1,191 ppm for 10 minutes has resulted in vertigo, pressure in the head, and somnolence [von Oettingen 1937].

Vapor Pressure

201 mm Hg

Odor Threshold Low

0.08 ppm

Odor Threshold High

17 ppm

Lethal Concentration

LC50 (mice) = 21,723 ppm/6H (trans-isomer);

Explosive Polymerization

Yes

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; VP = 180-265 mm Hg; Flash point = 2 deg C;

Reference Link

ATSDR - ToxFAQs - 1,2-Dichloroethene

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: