Agent Name

1,1,2,2-Tetrabromoethane

Alternative Name

Acetylene tetrabromide

CAS Number

79-27-6

Formula

C2-H2-Br4

Major Category

Solvents

Synonyms

Symmetrical tetrabromoethane; TBE; Tetrabromoacetylene; Tetrabromoethane; Acetylene tetrabromide; [NIOSH] Muthmann's liquid; sym-Tetrabromoethane; [ACGIH] UN2504

Category

Brominated Solvents

Description

Pale-yellow liquid with a pungent odor similar to camphor or iodoform; Note: A solid below 32 degrees F; [NIOSH]

Sources/Uses

Used as a solvent, ore flotation agent, catalyst, and flame-proofing additive; [ACGIH]

Comments

Some animals exposed at 4 ppm for 180 days show mild lung and liver injury. One nearly fatal human case with prominent liver injury was reported. The exposure was estimated at 16 ppm for 10 minutes. Other chemicals may have been involved. Findings in another human case were that of solvent-induced encephalopathy. Direct skin contact can cause second degree burns. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects and liver damage; [ICSC]

Reference Link

NIOSH Occupational Health Guidelines for Chemical Hazards: Acetylene tetrabromide

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.1 ppm, inhalable fraction and vapor

PEL (OSHA)

1 ppm

IDLH (NIOSH)

8 ppm

Excerpts from Documentation for IDLHs

Van Haaften [1969] reported that a chemist who had been exposed to 1 to 2 ppm for 7.5 hours, with only a single 10-minute exposure at 16 ppm, almost died from liver damage.

Vapor Pressure

0.02 mm Hg

Lethal Concentration

LC50 (rat) = 549 mg/m3/4H

Explanatory Notes

See "2018 Notice of Intended Changes." [TLVs and BEIs]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Primary

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: