Agent Name

Methylene blue trihydrate

CAS Number

7220-79-3

Formula

C16-H18-N3-S.Cl.3H2-O

Major Category

Dyes

Synonyms

Methylene Blue trihydrate; Methylene blue [USP]; 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride trihydrate; C.I. Basic Blue 9 trihydrate; Methylene Blue; C.I. Basic Blue 9, trihydrate (8CI); Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate; [ChemIDplus] 3,7-Bis(dimethylamino)phenazathionium chloride trihydrate; 3,7-Bis(dimethylamino)phenothiazin-5-ium, chloride, trihydrate; Methylthionine chloride trihydrate; Tetramethylene blue trihydrate; Tetramethylthionine chloride trihydrate; [CAMEO] MBLU; [NTP]

Category

Azine Dyes

Description

Dark green odorless solid with a bronze luster; [Merck Index] Hygroscopic; [CAMEO] Dark green powder; [Sigma-Aldrich MSDS]

Sources/Uses

Used as a bacteriological stain, redox colorimetric agent, and in medicine (antimethemoglobinic); [Merck Index] Used to dye cotton and wool; [NTP]

Comments

A skin and severe eye irritant; Toxic by ingestion (nausea, vomiting, diarrhea, dysuria, and hemolytic anemia from large doses); Repeated-dose oral studies of rats and mice demonstrated methemoglobinemia and a regenerative Heinz body anemia with secondary organ injury; Some evidence of carcinogenicity in male rats and mice, equivocal evidence in female mice, and no evidence in female rats; [NTP] A skin and strong eye irritant; Harmful by ingestion; Targets the blood, CNS, and eyes; May induce methemoglobinemia; [Sigma-Aldrich MSDS] See "Methylene blue."

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: